The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan

Updated precision measurement of the average lifetime of B hadrons

The measurement of the average lifetime of B hadrons using inclusively reconstructed secondary vertices has been updated using both an improved processing of previous data and additional statistics from new data. This has reduced the statistical and systematic uncertainties and gives \tau_{\mathrm{B}} = 1.582 \pm 0.011\ \mathrm{(stat.)} \pm 0.027\ \mathrm{(syst.)}\ \mathrm{ps.} Combining this result with the previous result based on charged particle impact parameter distributions yields \tau_{\mathrm{B}} = 1.575 \pm 0.010\ \mathrm{(stat.)} \pm 0.026\ \mathrm{(syst.)}\ \mathrm{ps.

Limits on the production of scalar leptoquarks from Z (0) decays at LEP

A search has been made for pairs and for single production of scalar leptoquarks of the first and second generations using a data sample of 392000 Z0 decays from the DELPHI detector at LEP 1. No signal was found and limits on the leptoquark mass, production cross section and branching ratio were set. A mass limit at 95% confidence level of 45.5 GeV/c2 was obtained for leptoquark pair production. The search for the production of a single leptoquark probed the mass region above this limit and its results exclude first and second generation leptoquarks D0 with masses below 65 GeV/c2 and 73 GeV/c2 respectively, at 95% confidence level, assuming that the D0lq Yukawa coupling alpha(lambda) is equal to the electromagnetic one. An upper limit is also given on the coupling alpha(lambda) as a function of the leptoquark mass m(D0)

Enhanced power to detect bioterrorism with spatial clustering (abstract)

Si tratta di Published abstract su Pediatric Research 51 (No 4 Pt 2) 132

Transienten-Untersuchungen in der PKL-Versuchsanlage (PKL III A). Bd. 1 Versuchsergebnisse. Abschlussbericht

The thermohydraulic response on the primary and secondary during transients with and without a break were investigated in the PKL Integral test facility. The results show that: isolating one, two or three of four SGs does not lead to stalling of existing steady state natural circulation in the isolated SGs; the growth of an upper plenum steam bubble during shutdown under loss of-off-site power conditions is limited to 0,3 m above the primary loops - for this reason normal shutdown procedures are not impeded by the steam bubble; the voiding of the SG-U-tubes of an isolated SG under shutdown conditions (50 K/h) interferes neither with the natural circulation flow in the intact SGs nor with the capability to depressurize the primary; the pressure drop on the secondary following injection of cold emergency feed water is also lower than expected; the RPV-level-probe responds at 90% water inventory; the result of the LOBI and PKL Counterpart test show good agreement. (orig.)In der Integralversuchsanlage PKL wurden im Rahmen der Versuchsreihe III A thermohydraulische Vorgaenge im Primaer- und Sekundaersystem bei Transienten und kleinen Lecks untersucht. Die Ergebnisse zeigen, dass: Die sekundaerseitige Isolation von einem, zwei oder drei von vier DEs nicht zum Erliegen des stationaeren Naturumlaufs in den betroffenen Straengen fuehrt. Das Wachstum der Deckelblase beim Abfahren im Notstromfall auf eine Hoehe von 0,3 m oberhalb der HKL begrenzt wird - aus diesem Grund wird das Abfahren der Anlage durch die Deckelblase nicht behindert. Das Ausdampfen der DE-U-Rohre bei isolierten DEs und Abfahren mit 50 K/h behindert weder den Naturumlauf in den intakten DEs, noch die Druckabsenkungen im Primaerkreis. Der Druckabfall auf der Sekundaerseite nach Einspeisung von kaltem Notspeisewasser niedriger ist als erwartet. Die RDB-Sonde in einem kleinen-Leck-Szenario bei 90% Inventar anspricht. Die Ergebnisse des LOBI/PKL Counterpart Tests gut uebereinstimmen. (orig.)SIGLEAvailable from TIB Hannover: RO 7152(1989,15a) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman